EteRNA and Deadly Strangers

Similar to Foldit—created by some of the same researchers that developed EteRNA—the puzzles take advantage of human problem-solving capabilities to solve puzzles that are computationally laborious for current computer models. The researchers hope to capitalize on "crowdsourcing" and the collective intelligence of EteRNA players to answer fundamental questions about RNA folding mechanics. The top voted designs are synthesized in a Stanford biochemistry lab to evaluate the folding patterns of the RNA molecules to compare directly with the computer predictions, ultimately improving the computer models.

Ultimately, EteRNA researchers hope to determine a "complete and repeatable set of rules" to allow the synthesis of RNAs that consistently fold in expected shapes. EteRNA project leaders hope that determining these basic principles that may facilitate the design of RNA-based nanomachines and switches. EteRNA creators have been pleasantly surprised by the solutions of EteRNA players, particularly those of nonresearchers whose "creativity isn't constrained by what they think a correct answer should look like".

As of August 2011, approximately 26,000 players have contributed RNA sequence designs and over 306 designs have been synthesized for in vitro testing. In January 2014, the results from EteRNA have been published in the PNAS journal, with "EteRNA participants" listed as co-authors in the paper.

Contents 1 Gameplay 2 See also 3 References 4 External links

Gameplay

Players are presented with a given target shape into which an RNA strand must fold. The player can change the sequence by placing any of the four RNA nucleotides (adenine, cytosine, guanosine and uracil) at various positions; this can alter the free energy of the system and dramatically affect the RNA strand's folding dynamics. In EteRNA, different restrictions, such as those on the number of certain bases and the number of the three base-pair types, as well as locked bases, are sometimes imposed. A molecule is occasionally also included, which binds with the RNA and has critical effects on the free energy of the system. In some more advanced puzzles, players may be presented with two or three different target shapes at the same time; the single sequence the player produces must fold in the respective shapes under different conditions (presence or absence of a binding molecule).

EteRNA puzzles are roughly classified into three types: Challenges, Player Puzzles, and Cloud Lab. Challenges are the puzzles prepared by the game-makers to introduce players to the workings of EteRNA as well as to provide series of pre-set puzzles for players to attempt. Player puzzles are generated by players, and Cloud Lab is where the active, proposed and archived laboratory projects are presented for players to review, vote or attempt.

Once players have completed a sufficient number of RNA puzzles, they unlock the chance to generate puzzles for other players. These puzzles can be selected as future synthesis candidates if they fit certain rules and prove interesting. Other more complex puzzles are not currently lab synthesis candidates. See also Citizen science Foldit Game with a purpose List of crowdsourcing projects Serious game

Deadly Strangers and EteRNA

Contents 1 Plot 2 Cast 3 Critical reception 4 External links 5 References

Plot

A lunatic is on the loose as a salesman, Steven Slade (Simon Ward) picks up a young lady, Belle Adams, (Hayley Mills) in a blue Austin Maxi car after she is nearly raped by a lorry driver.

Adams wishes to catch a train at a nearby station and Slade in wishing to take her there (really wishing to exploit her) lies about delays in her train as a way of keeping her with him.

With roadblocks in the area and Slade not being too forthcoming on his own background, the trip sharply descends into a case of what are they both hiding. This is never fully revealed.

On waking the next morning Slade loses Adams and hurries off to find her, where she misses him and catches a lift from aging Malcolm Roberts (Sterling Hayden). Later Roberts discovers Adams past and the truth of the film has yet to be uncovered. Cast Belle Adams - Hayley Mills Stephen Slade - Simon Ward Malcolm Robarts - Sterling Hayden Jim Nicholls - Ken Hutchison Belle's Uncle - Peter Jeffrey Café Owner - Hubert Tucker Petrol Station Attendant - Nina Francis 1st Motorcycle Youth - George Collis 2nd Motorcycle Youth - Ralph Arliss Stephen's Girlfriend - Juliet Aykroyd Motorcycle Policeman - Roger Nott Hotel Receptionist - Norman Tyrrell Critical reception

Time Out noted "old-fashioned psychopathic goings-on in the West Country" and its "sole redeeming feature is Hayley Mills, who suggests an actress capable of much better things than she has been offered recently. Hayers, to his credit, does exploit her best quality - an insolent, slightly offhand sex appeal" ; while TV Guide found it an "occasionally intriguing tale," concluding that it was "well done, but it seems to bog down in its own cleverness"; whereas The Terrror Trap found it "a satisfying and well made British psycho thriller." External links Deadly Strangers at the Internet Movie Database
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