John Steigerwald and Growth hormone releasing hexapeptide

John Steigerwald (born October 3, 1948), is a Pittsburgh based sports reporter, commentator, and former sports anchor and second oldest member of the Steigerwald media family that includes his older brother Bill and younger brothers Paul Steigerwald and rock guitarist Dan Steigerwald. John worked on the sports anchor team at WTAE-TV (ABC), along with other Pittsburgh notables such as Myron Cope and Bill Hillgrove. He later moved to KDKA-TV (CBS) in 1985 and was an anchor and primary Pittsburgh Steelers reporter for 30 years. KDKA chose not to renew his contract in 2007. Currently, he is a "Sports Talk" host on the radio website of the Pittsburgh Tribune-Review. His brother Bill Steigerwald is an ex-newspaperman and book author ("Dogging Steinbeck") who worked at the Los Angeles Times in the 1980s, the Pittsburgh Post-Gazette in the 1990s and the Pittsburgh Tribune-Review in the 2000s. Paul Steigerwald, a former KDKA-TV sports reporter, is the Pittsburgh Penguins television play-by-play announcer. Bryan Stow incident

Steigerwald, whose opinionated and often politically incorrect weekly sports column has run in Pittsburgh daily newspapers for 25 years, was the focus of much controversy in 2011 after San Francisco Giants fan Bryan Stow was severely beaten on Opening Day at Dodger Stadium in Los Angeles. In his column for the Washington Observer-Reporter Steigerwald wrote: "Maybe somebody can ask Stow, if he ever comes out of his coma, why he thought it was a good idea to wear Giants gear to a Dodgers’ home opener when there was a history of out-of-control drunkenness and arrests at that event going back several years." Steigerwald, who had commented many times in his column that adult fans should "grow up" and not wear replica jerseys to their teams' games, was accused by sports bloggers around the country of blaming Stow for the incident. He defended himself vigorously on national TV and in print, arguing that blog headlines like “Jerk in Pennsylvania says Giants Fan Deserved It” and “Pennsylvania Columnist Says Stow had it Coming” completely misrepresented what he wrote. He later admitted that his comments about Stow's beating "came across as flippant and insensitive" but wrote "That was not my intent. If I had it to do over again, I would write it differently. I know what I felt in my heart when I wrote it and it was anger over what had happened to this guy over a stupid jersey." Books

Steigerwald is also a published author.

Just Watch the Game (2010) Just Watch the Game Again (2011)

Growth hormone releasing hexapeptide and John Steigerwald

Growth hormone releasing hexapeptide (GHRP6) is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids, were developed for their growth hormone (GH) releasing activity and are called GH secretagogues. They lack opioid activity but are potent stimulators of GH release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through action at a completely different receptor. This receptor was originally called the GH secretagogue receptor, but due to subsequent discoveries, the hormone ghrelin is now considered the receptor's natural endogenous ligand. Therefore, these GH secretagogues act as synthetic ghrelin mimetics. Technical data

It has also been discovered that when GHRP-6 and insulin are used simultaneously, GH response to GHRP-6 is increased (1). However, the consumption of carbohydrates and/or dietary fats, around the administration window of GH secretagogues significantly blunts the GH release. A recent study in normal mice showed significant differences in body composition, muscle growth, glucose metabolism, memory and cardiac function in the mice being administered the GHRP-6 (2). There are still many questions regarding this fairly new compound, scientists are hoping to gain a better clinical understanding of the peptide through further research over the next few years.

GH secretagogues differ from exogenous rHGH in their effects primarily due to the fact that endogenous GH contains all 5 isoforms of growth hormone, whereas exogenous GH contains only the 20 kilodalton isoform. Different isoforms affect tissues in discreet ways that the 20 kDa isoform cannot. Administration of GH secretagogues causes a pulse-release of GH from the pituitary which is cleared from the body within a few hours. This does not significantly raise plasma IGF1 levels.
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